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Buy Doxycyline Online
Doxycyline is a tetracycline antibiotic used to treat infections of urinary tract, acne, gonorrhea, chlamydiosis, periodontitis, etc.
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Pack quantity: 60
Release form: Pills
Manufacturer: Pharmaceuticals Inc., Canada
What is Doxycycline?
Tetracycline antibiotics, which include Doxycycline, have a wide spectrum of action. This semisynthetic antibiotic has a bacteriostatic effect on microorganisms - it inhibits the ability of microbes to multiply in the body. The antibiotic penetrates the cells of microorganisms and blocks the synthesis of proteins there.
Doxycycline has an effect on a large number of microbes - causative agents of aerobic (requiring oxygen for development) and anaerobic (they can develop without oxygen) infections.
To doxycycline susceptible streptococci and staphylococci, E. coli and Salmonella, dysentery bacillus, Klebsiella and clostridia, agents highly dangerous infections (cholera, plague, anthrax and tularemia) infections, sexually transmitted diseases (syphilis, gonorrhea, chlamydia, ureaplasmosis), malarial Plasmodium and other pathogens.
A wide range of action of the drug is particularly important in cases where the causative agent of the disease could not be established for one reason or another. And some diseases, such as pneumonia, can be caused by various microorganisms.
Doxycycline has no effect on fungi and viruses.
How long does it take for Doxycycline to work for bacterial infection?
Treatment of a bacterial infection with Doxycycline takes about one to two weeks, depending on the severity of the disease. To comply with the rules of taking the drug, treatment should be carried out under the supervision of a physician. It is impossible to assert that Doxycycline is the best drug for any disease. the choice of antibiotic depends on the pathogen and its sensitivity, and on the severity of the disease, and on the presence of comorbidities in the patient, and sometimes on the financial capacity of the patient.
How long does doxycycline stay in your system?
When administered inside the drug is almost completely absorbed in the stomach. Eating does not affect the absorption of the drug. 2 hours after taking the antibiotic reaches its maximum concentration in the blood plasma and binds to plasma proteins (up to 95%). Therapeutic plasma concentration after a single dose is kept for 15-16 hours, with repeated – 18-24 hours. This allows you to take doxycycline 1 time per day.
Excreted unchanged in the urine (40%) and feces (40%). It accumulates in the bone tissue and dentine (the main tissue of the teeth).
Indications for use
The wide spectrum of action of Doxycycline allows it to be used to treat a large number of infections whose pathogens are sensitive to this antibiotic:
- respiratory diseases (acute and chronic bronchitis, pneumonia, lung abscess and pleural empyema, pleurisy);
- urinary tract infections (urethritis, pyelonephritis);
- infections of upper respiratory tract (otitis, sinusitis or inflammation of the paranasal sinuses, angina);
- intestinal infections (dysentery, salmonellosis, typhoid fever, cholera, and others);
- diseases of the pelvic organs in men and women (endometritis, salpingoophoritis, epididymitis, prostatitis);
- inflammatory diseases of the gastrointestinal tract (cholecystocholangitis, proctitis, peritonitis);
- infections of soft tissue and skin (furunculosis, carbuncle, acne);
- sexually transmitted infections (primary and secondary syphilis, gonorrhea, ureaplasmosis, chlamydia);
- many infectious diseases (brucellosis, typhoid, rickettsiosis, Q fever, yersiniosis, borreliosis, tularemia, whooping cough, leptospirosis and others);
- eye diseases (trachoma, ulcerative keratitis);
- osteomyelitis, etc.
For preventive purposes, doxycycline is prescribed:
1. For the prevention of malaria during a short (up to 4 months) stay in an area where resistance to Pirmethamine-sulfadoxine and Chloroquine is noted;
2. To prevent complications after surgery on the colon and after medical abortion.
The dose of the drug, the optimal frequency of taking the medicine and the duration of the course of treatment are determined by the doctor.
A single dose for oral administration and intravenous drip is 100-200 mg, the daily maximum dose is 300-600 mg for oral administration and 300 mg for intravenous administration. Doses depend on the type of pathogen and the severity of the patient’s condition. Usually prescribed on the first day of treatment 200 mg, then 100 mg per day. In some cases, appoint 200 mg per day for the entire period of treatment.
For adolescents, the doses of doxycycline are the same as for adults.
For children weighing more than 45 kg, a dose of 4 mg per 1 kg of body weight is prescribed on the first day of treatment, regardless of the route of administration of the medicine, and on subsequent days, at the rate of 2-4 mg per 1 kg of body weight.
How to take Doxycycline?
It should strictly observe the prescribed dosage of the drug. The daily dose can be taken once at the same time of day, and can be divided into 2 doses in 12 hours.
The drug should be taken after meals and drink plenty of fluids (preferably water). For the entire period of taking the drug, plenty of drink is recommended.
Some scientists recommend drinking the drug with milk to prevent side effects from the stomach. But other researchers hold the opposite opinion, explaining that Doxycycline forms an insoluble compound with calcium from milk, and thereby reduces the effect of its action.
It is undesirable to use fresh fruit while taking doxycycline, because they can irritate the gastric mucosa and contribute to the occurrence of side effects on the part of the digestive system.
Even some trace elements and vitamins can affect the efficacy of doxycycline. Therefore, we must be careful with the simultaneous use of dietary supplements (dietary supplements) during treatment with doxycycline; It is best to discuss this issue with your doctor.
Doxycycline and Alcohol
Doxycycline has an adverse effect on the central nervous system. This is manifested in the form of dizziness, headache. Alcohol also has a strong neurotoxic effect. When taken simultaneously (or with a short period of time) and Doxycycline, and alcohol, their toxic effects are inevitably increased.
Doxycycline as well as other antibiotics, is not combined with alcohol intake. The simultaneous use of alcohol and doxycycline can cause migraine-like headache, retching, coordination problems. The effect of alcohol on the efficacy of doxycycline may be twofold: sometimes there is a weakening of the therapeutic effect of the drug, sometimes – its strengthening.
Since drugs and alcohol decompose in the liver, drinking alcohol during treatment leads to an increase in the load on the liver and the risk of reactive hepatitis.
Therefore, taking alcohol during doxycycline treatment is clearly prohibited. If doxycycline is used prophylactically 1-2 times a week, then you can drink alcohol through
Doxycycline for chlamydia
Recent studies have shown that three groups of antibiotics are effective for the treatment of chlamydia: tetracyclines, fluoroquinolones and macrolides.
In uncomplicated forms of chlamydia (urethritis, cervicitis and carriage of chlamydia without manifestations of the disease) Doxycycline is the most preferred of all tetracyclines, since appointed in lower dosages (100 mg) and only in 1 or 2 doses per day.
Even more effective in chlamydia and the Doxycycline analog, Unidox Solutab, is convenient in administration.
When chlamydia is combined with other infections, the selection of antibiotics is carried out individually in accordance with the sensitivity of the isolated flora. A good result of the treatment of inflammatory manifestations in the pelvic organs is observed with the combined appointment of Doxycycline (100 mg per day) and Metronidazole (500 mg 2 times a day).
Currently, when chlamydia Doxycycline is prescribed at any stage of the disease. Doses of the drug, treatment regimen, the duration of the course are selected individually depending on the characteristics of the manifestation of the process.
The problem with the treatment of chlamydial infection is that if the treatment is not properly carried out, the disease becomes chronic. Therefore, to change the dose or duration of treatment should not be. Chronization process also contributes to the reduction of immunity. Therefore, treatment should be comprehensive and include immunomodulators (Dekaris, Timalin, Methyluracil, Pantocrin, and other drugs).
Doxycycline for acne
Acne (acne) is a disease of the sebaceous glands and hair follicles. Persons of young age and teenagers often meet with this disease (80%).
With abundant acne rash, antibiotic therapy is indicated. One of the drugs prescribed for acne is Doxycycline with its broad spectrum of action. Its effectiveness in the treatment of acne is also explained by the fact that it is highly soluble in fats and is able to penetrate into the ducts of the sebaceous gland and the hair sac. Therefore, doxycycline has advantages in choosing an antibiotic for the treatment of acne. Matters and low price of the drug.
Severe acne should be treated by a dermatologist. He will select the dose of the drug and observe it in the course of treatment, and, if necessary, prescribe an external treatment. Intermittent antibiotic courses are used more often for a long time.
The use of doxycycline in acne gives a stable and long-lasting remission of the disease.
Doxycycline with a tick bite
The causative agent of tick-borne relapsing fever (borrelia) is transmitted by ticks when it bites. Therefore, it should be investigated in laboratories for research.
Considering that the incidence of borreliosis is high, then a positive response from the laboratories (i.e. tick infestation) is prescribed a preventive course of doxycycline for 3-5 days at 200 mg per day for 2 doses. Children over 8 years old – 4 mg per 1 kg of body weight. Children up to 8 years old are prescribed Augmentin or Zithromax preventive course.
After the tick bite. With a timely and properly conducted course, Doxycycline is effective for the prevention of borreliosis.
The course of antibiotics is not conducted.
What are the side effects of Doxycycline?
Doxycycline may cause such side reactions:
On the part of the digestive system – nausea, vomiting, abdominal pain, loss of appetite, abnormal stools (constipation or diarrhea), impaired swallowing, tongue inflammation, inflammation in the area of the intestinal outlet, or less inflammation or ulceration of the esophagus, stomach and duodenum , a transient increase in blood levels of bilirubin, alkaline phosphatase and hepatic transaminases.
On the part of the nervous system – an increase in intracranial pressure, which is manifested by headache, dizziness, vomiting, visual impairment.
On the part of the blood, a decrease in the number of neutrophilic forms of leukocytes, a decrease in the number of platelets, an increase in the number of eosinophils in the blood (indicating an allergic mood of the organism); hemolytic anemia (anemia due to the destruction of red blood cells or red blood cells).
Allergic reactions – itching, rash on the skin; rarely, shortness of breath, angioedema, or angioedema (sudden developing, limited or diffuse swelling of the mucous membranes and subcutaneous fat); anaphylactic shock (very severe manifestation of life-threatening allergy), photosensitivity (hypersensitivity of mucous membranes and skin to ultraviolet rays), Lyell’s syndrome (the most severe manifestation of allergic dermatitis with tissue necrosis), pericarditis (inflammation of the outer cardiac membrane).
Children under 8 years old may have discoloration of the teeth and delayed growth of the skeleton.
In the event of severe adverse reactions, doxycycline should be discontinued promptly.